We present The Medicine Maker 2020 Power List, which celebrates the great minds involved in the development of all therapeutics, from small molecules to biopharmaceuticals to advanced medicines. The list includes 60 inspirational professionals. Meanwhile in Upfront, researchers use silver nanoparticles to battle brain-eating amoeba, and a new drug to heal broken bones more quickly. In NextGen, we find out why plants could help accelerate the manufacture of a COVID-19 vaccine, and how lessons learned from decades of manufacturing mAbs are affecting processes for cell and gene therapies. Finally, we sit down with Stephen Tindal to discuss pharma forensics and mystery solving.