Despite being an increasingly popular method of inhaled drug delivery, dry powder inhalers (DPIs) have relatively low effectiveness in delivery of the active ingredient. Research from Monash University highlights the value of using a Spraytec laser diffraction particle size analyzer to generate powder de-agglomeration profiles which show how dose dispersion changes as a function of the applied air flow rate. This allows efficient comparison of the dispersion performance of different formulations in a device, supporting the efficient matching of devices to formulations.
Key Points:
- Dry powder inhalers (DPIs) are becoming increasingly popular for inhaled drug delivery but their effectiveness in active ingredient delivery is relatively low
- Improving the efficiency of drug delivery by DPIs relies on understanding and controlling formulation de-agglomeration
- Spraytec delivers real-time measurement of particle size during device actuation, enabling the generation of a ‘de-agglomeration profile’ that describes how formulation dispersion changes as a function of the applied air flow rate
- The performance of different DPI formulations in a device can be assessed by measuring and comparing their de-agglomeration profiles
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Malvern Instruments provides the materials and biophysical characterization technology and expertise that enable scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency. Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment. Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications. Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, Mexico, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com severine.michel@malvern.com
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