November 24, 2015
Protein/Protein interactions define a large fraction of the validated targets for drug development including cancer, inflammation, diabetes, osteoporosis, infection and autoimmune diseases.
1 min read
November 23, 2015
Extractables and leachables testing is essential for small molecule and biopharmaceutical products alike, but it can be challenging, especially for companies with less experience. Are you making the most of technological advances that can make analysis easier – and your drugs safer?
1 min read
November 23, 2015
Advanced digital technologies are sweeping through the world and changing the way we live our lives and do business. And although change is often disruptive, digital technology is allowing pharma to reap the benefits of advanced analytics like never before.
1 min read
November 23, 2015
Sitting Down With... Siu Ping Lam, Director of Licensing Division at the UK’s Medicines and Healthcare products Regulatory Agency (MHRA).
1 min read
November 23, 2015
Starting my own bioanalytical research company after many years working for Big Pharma has been daunting, but also satisfying, and I wouldn’t have missed it for the world. Here, I describe my journey from naïve beginnings to fully functional lab and the steep learning curve that led the way.
1 min read
November 23, 2015
“The best-laid schemes o’mice an’ men” often go awry – and that can apply to your outsourcing plans. What do you do if your contractor ends up in the regulators’ bad books?
1 min read
November 23, 2015
Battling logjams in downstream processing is a constant challenge, but even when it feels like there’s no room for maneuver, small yet clever steps can help gain efficiency. And sometimes a fresh pair of eyes can find new and surprising solutions.
1 min read
November 23, 2015
Bacterial infection is only treated when we see signs of infection, but what if we could treat earlier and without adding to drug resistance? I’m a believer in the power of endolysins.
1 min read
November 23, 2015
Whether you are a global corporation or a tiny biotech, changing your company name is more than updating your letterheads and putting a new sign on the door. Get it wrong and it could be a costly mistake, but get it right and it’s an exciting step towards a whole new image.
1 min read
November 23, 2015
In an industry as diverse as pharmaceuticals, there is much that different disciplines can learn from each another. Here, I present a few potential sparks of inspiration by asking if and how the world of drug delivery can benefit from a more holistic use of the innovations occurring all around us – and vice versa.
1 min read
November 20, 2015
What comes first – product innovation or process innovation? For biopharmaceuticals, the two should be inseparable.
1 min read
November 20, 2015
The 2015 Nobel Prize in Physiology or Medicine praises advances in parasitic tropical diseases
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November 20, 2015
A newly approved oncolytic immunotherapy takes on cancer using a live modified herpes virus
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November 20, 2015
Could an ionic liquid–drug system help solve drug insolubility?
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November 20, 2015
Can certain buzzwords really sway public perceptions of a new drug?
1 min read
November 20, 2015
How to dress drugs to help them survive in the bloodstream
1 min read
November 20, 2015
Can lettuce really help biopharmaceuticals turn over a new leaf? Researchers who have bioencapsulated blood-clotting factors inside salad leaves as a means to create affordable biologics certainly think so
1 min read
November 20, 2015
Round and round she goes, where she stops nobody knows.
1 min read
November 16, 2015
Temperature-induced unfolding of three humanized IgG1 monoclonal antibodies and their Fab and Fc fragments was monitored by differential scanning calorimetry at neutral pH. With some exceptions, the thermogram of the intact antibody presents two peaks and the transition with the larger experimental enthalpy contains the contribution from the Fab fragments. Although the measured enthalpy was similar for all three Fab fragments studied, the apparent melting temperatures were found to vary significantly, even for Fab fragments originating from the same human germline.
1 min read
November 16, 2015
In this report, we illustrate the utility of calorimetry in making better laboratory decisions. Examples will include improved protein construct selection for scale-up; direct measurement of the effects of mutations and post-translational modifications on protein stability; rapid optimization of solvent formulation; direct measurement of substrate and inhibitor binding affinity; determination of the mode of inhibitor binding; characterization of protein-protein interactions; and improved structural biology efficiency, when used in conjunction of other biophysical methods.
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