July 2015

Studying low-affinity fragments of ligands by ITC

Nanoparticle Tracking Analysis: Principles and Methodology

Nanoparticle Tracking Analysis represents a rapid and information-rich multi-parameter nanoparticle characterization technique allowing the user to obtain number frequency particle size distributions of polydisperse nanoparticulate systems. It has resulted in its rapid adoption as an interesting new technique in a wide range of sectors within the pharmaceutical sciences. This Chapter 5 addresses some of the latest work reported in the literature in which NTA has been proposed, used and assessed in the study of nanoparticle-based drug delivery and targeting.

Laser diffraction and automated imaging: complementary techniques for nasal spray development

A Cat and Mouse Game: The Evolving Landscape of Abuse-Deterrent Formulations

Abusers are finding ways to circumvent current abuse-deterrent measures, leaving companies in need of new strategies. Alyn McNaughton, Director of Analytical and Product Development at Encap Drug Delivery, a division of Capsugel Dosage Form Solutions, and Shonagh Walker, Formulation Scientist at Encap Drug Delivery, talk us through some of the challenges.

Decision Support

Suzanne Farid is Professor of Bioprocess Systems Engineering and Co-Director of the ESPSRC Center for Innovative Manufacturing in Emergent Macromolecule Therapies hosted by the Department of Biochemical Engineering at University College London. Farid and her team have developed a range of software tools to help biopharma companies make decisions on the best manufacturing processes, including whether to make the switch to continuous.

Recall Roundup

Several companies are faced with recall woes thanks to insects, dodgy closures and broken tablets

Is Biopharma Ready to Say Goodbye to Batches?

Very few biologics are made using continuous processing equipment like bioreactors. Clearly, the biopharmaceutical industry has a long way to go before it’s ready to embrace (potentially) superior manufacturing models. Why?

Holistic Bioanalytics in the Clinic

Lawrence (Larry) Lesko is a bioanalytical veteran with many years of academic and FDA experience under his belt. Now, as director of the University of Florida’s Center for Pharmacometrics and Systems Pharmacology, Larry uses metabolomics to discover biomarkers of drug toxicity.

The Medicine Maker Innovation Awards 2015

The December issue will feature our inaugural Innovation Awards, recognising the most exciting new technologies of 2015.

Addiction by Prescription

Prescription drug abuse has already reached epidemic proportions in the US – and other countries look set to follow the dangerous trend. What can drug makers do to help stem the tide?

Precision Biomanufacturing

Personalized medicine looks set to transform the biopharmaceutical landscape, and will demand significant changes in production methods. The demand for large-scale batch processes will decline – so what is the alternative? The UK’s new National Biologics Manufacturing Center is on a mission to answer that very question.

Fighting Fear – the Entrepreneur’s Enemy

The true path to success as an entrepreneur is the ability to spot high impact problems – and to be fearless in the pursuit of great solutions.

The Business of Biosimilars

Sitting Down With… Carsten Brockmeyer, CEO, Formycon, Germany.

Fake Medicine, Genuine Risk

How can we fight the global pandemic of falsified and substandard medicines?

Multimodal Spectroscopy: Production Workhorse

Manufacturing is getting smarter; only a cross-discipline approach will ensure the success of tomorrow’s processes.

A Blast From Potions Past

Are ancient texts hiding the answer to antibiotic resistance?

Biomimetic Protection of Biomolecules

Porous shells – inspired by sea urchins – help defend biomacromolecules from the outside world

(Anti)Bacterial Factory

Engineered E. coli colonies could be trump cards in the war against drug resistance

Riddle Me This, Biosimilar

The first US biosimilar – Zarxio from Sandoz – has been cleared for market. But the judges say it wasn’t an easy decision

Green Light for Malaria Vaccine

After 28 years of R&D at GSK, the world has its first malaria vaccine

Highly Potent; Highly Targeted

A new mathematical model aims to improve drugs for cancer, viruses and bacteria

The Epidemic That Cannot Be Ignored

Prescription drug abuse is not just a US problem.